Importance of repairing your DNA and how NMN helps
DNA encodes the cell's genome and is a permanent copy of a structure vital for the proper functioning of the cell. Any changes in the structure of the DNA lead to the mutation and genomic instability that cause cancer. The damage to DNA is caused due to the fusion of a nucleotide's incorrect bases during the chemical changes and DNA replication by exposure to the environmental factors or mutation. Here’s the importance of repairing your DNA and how NMN helps you. Are you ready? Let’s get started!
Importance of repairing your DNA:
As you grow older, DNA damage will also increase due to external factors such as pollution, radiation, and indefinite DNA replication. The current aging theory suggests that the main cause of aging is the accumulation of DNA damage. Almost all the cells have the molecular machinery to repair DNA. Excessive DNA damage leads to chronic diseases.
DNA repair processes are found in the eukaryotic and prokaryotic organisms. The cells evolve several mechanisms to detect the damage and repair DNA either the damage is caused by the environment or by errors in replication. DNA is a molecule that has significance in the division, and control of DNA repair is linked to the cell cycle’s regulation. Recall that cell transfer through the cycle involving phases G1, G2, S, and M. The DNA replication occurs in the S phase during mitosis in the M phase.
The checkpoint mechanisms confirm that DNA is intact during the cell cycle before allowing DNA replication and cell division. The accumulation of damage occurs due to the failures in these checkpoints that lead to mutations. Defects in DNA repair come with several genetic diseases that affect several body systems that, in turn, lead to cancer. Some other disorders include AT (ataxia-telangiectasia), which is a degenerative motor condition due to the failure of the repair damage in xeroderma pigmentosum and cerebellum. The xeroderma pigmentosum is a skin condition in which the patient is sensitive to the sunlight and associated with a defect in the UV damage repair pathway. The above discussion shows why DNA damage repair is necessary or why it is important.
How NMN helps in DNA repair:
NMN is an acronym of nicotinamide mononucleotide that is found in all organisms. This molecule is a ribonucleotide at a molecule level, which is the structural unit of RNA. It is composed of phosphate, a ribose, and a nicotinamide group. NMN is the originator of the NAD+ (nicotinamide adenine dinucleotide). NMN boosts the NAD+ levels, allowing PARP1 (Poly (ADP-ribose) polymerase -DNA repair protein) to function properly. PARP depends on NAD+ to function. NMN improved the cells' ability to repair the DNA damage, which is caused by the exposure of radiation. When you grow old, the level of NAD+ decreases. The accumulation of DNA damage leads to increased PARP, which causes a decrease in NAD+ concentration. Research suggests that NMN helps in DNA repair to keep chronic diseases at bay.