I’m not a doctor, but I can share what current research suggests about supplements that may support people with Parkinson’s disease (PD). It’s crucial to talk with your healthcare provider before starting anything new, especially considering possible interactions with PD medications.
Supplements with Some Evidence of Benefit
Vitamin B₃ (Nicotinamide Riboside)
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Early-phase clinical trials (Phase 1) show that high-dose nicotinamide riboside can elevate NAD levels in the brain and may improve metabolism, reduce inflammation, and even mildly ease symptoms in some people with PD Parkinson's UK+1.
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Larger trials are currently underway.
Order Nicotinamide Riboside here
Mucuna pruriens (Velvet Bean)
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Contains natural L-DOPA. Small studies have found it to be as effective as synthetic levodopa in improving motor function, though tolerability varies NCCIHSpringerLink.
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A caution here: side effects like gastrointestinal discomfort and potential medication interactions are not uncommon Verywell Health.
Omega-3 Fatty Acids
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May reduce inflammation and offer mild motor benefits in some cases Parkinson's FoundationFood for the Brain.
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One trial suggested improved mental health and reduced depressive symptoms with omega-3 supplementation Food for the Brain.
Vitamin D
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Many people with PD are deficient, and vitamin D plays a role in brain health and inflammation modulation via BDNF support Food for the Brain.
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Recommended: get your levels tested and consider supplementation (e.g., 2,000 IU daily for deficiency), with follow-up testing Food for the Brain.
Order High Strength Vitamin D3 Here
CDP-Choline (Citicoline)
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Some evidence indicates it may help reduce tremors and rigidity by supporting dopamine and noradrenaline levels Healthline.
N-Acetyl Cysteine (NAC)
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A small 2019 study showed NAC improved dopamine transporter binding and had positive effects on motor and cognitive symptoms Healthline.
Glutathione
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A potent antioxidant, but clinical evidence of benefit in PD is limited. Oral or other forms haven't shown proven effectiveness thus far Parkinson's FoundationHealthline.
