⚡ Energy Metabolism

"Niacin contributes to normal energy-yielding metabolism"

🧠 Nervous System

"Niacin contributes to normal functioning of the nervous system"

🧘 Psychological Function

"Niacin contributes to normal psychological function"

💪 Tiredness & Fatigue

"Niacin contributes to the reduction of tiredness and fatigue"

🌿 Skin & Mucous Membranes

"Niacin contributes to the maintenance of normal skin and mucous membranes"

🛡️ Mucous Membranes

"Niacin contributes to the maintenance of normal mucous membranes"

🍇 Trans-Resveratrol — 250mg per capsule · Grape-Derived · CAS 501-36-0

Trans-resveratrol (3,5,4′-trihydroxy-trans-stilbene, CAS 501-36-0) is the biologically active isomeric form of resveratrol — a polyphenolic stilbenoid found naturally in grape skins, certain berries and peanuts. The resveratrol in this product is sourced from grape skin extract (Vitis vinifera) — the traditional dietary source. Most commercial resveratrol is extracted from Japanese knotweed (Polygonum cuspidatum) due to higher yield. Both sources yield chemically identical trans-resveratrol (CAS 501-36-0).

Trans-resveratrol has been studied extensively in published research, particularly in the context of sirtuin pathway interactions (SIRT1) and AMPK activation. Published literature on resveratrol is extensive — we link key references below. Note that oral bioavailability of resveratrol is typically less than 1% due to rapid first-pass hepatic metabolism — this is an honest characteristic of the compound. Educational context only — not health claims.

💊 B3 Nicotinamide (Niacinamide) — 250mg per capsule · Non-Flush · CAS 98-92-0

Nicotinamide (Niacinamide, CAS 98-92-0) is the amide form of vitamin B3 — the non-flush alternative to Nicotinic Acid. It does not activate GPR109A prostaglandin receptors, meaning it does not cause the skin redness and tingling associated with Nicotinic Acid even at higher doses. It has 6 authorised EU/UK health claims — listed in full above.

Nicotinamide is also a direct NAD+ precursor via the salvage pathway — converted to NMN then to NAD+ via the NAMPT enzyme. This is the mechanistic basis for combining it with resveratrol in this formulation. Educational context only — not a product claim beyond the 6 authorised claims above.

B3 Nicotinamide → NAD+ via Salvage Pathway

Nicotinamide converts to NAD+ via: Nicotinamide → (NAMPT) → NMN → (NMNAT) → NAD+. NAD+ is the coenzyme required for sirtuin enzyme activity — SIRT1, SIRT3, SIRT6. Providing a NAD+ precursor supports the substrate availability for sirtuin function. Educational context only.

Trans-Resveratrol — Published Sirtuin Research Context

Trans-resveratrol has been studied extensively for potential SIRT1 interactions. The exact mechanism remains debated — some published evidence suggests indirect SIRT1 activation via AMPK phosphorylation rather than direct binding. Robust human clinical trial evidence for the resveratrol + B3 Nicotinamide combination specifically is limited. Educational context only — not a product claim.

The Combined Rationale in One Capsule

B3 Nicotinamide provides the NAD+ substrate. Trans-resveratrol is studied for potential sirtuin pathway interactions. Together in one capsule they represent a convenient single-capsule approach to this pairing — with the legal benefit of carrying 6 authorised B3 health claims. Educational context — no combined human RCT exists for this specific pairing. Food supplement — not a medicine.

How much resveratrol and B3 is in each capsule?

250mg trans-resveratrol + 250mg B3 Nicotinamide = 500mg total per capsule. Not 500mg of each — 500mg total, split equally. For 500mg of each ingredient take 2 capsules daily.

Where is the resveratrol sourced from?

Grape skin extract (Vitis vinifera) — not Japanese knotweed. Both sources yield chemically identical trans-resveratrol (CAS 501-36-0). This is a sourcing transparency choice.

Does this cause a niacin flush?

No — this contains Nicotinamide (non-flush form), not Nicotinic Acid. Nicotinamide does not activate GPR109A receptors. No skin redness or tingling.

What is the UK regulatory status of trans-resveratrol?

High-purity trans-resveratrol is regulated as a novel food in Great Britain with specific authorised conditions. We declare this transparently. Review current FSA guidance before purchasing. Food supplement — not a medicine.

What are the authorised health claims?

6 authorised EU/UK claims for the B3 Nicotinamide component — energy metabolism, nervous system, psychological function, tiredness and fatigue, skin and mucous membranes. No authorised claims for trans-resveratrol. Food supplement — not a medicine.

Are there any fillers?

No. 250mg trans-resveratrol + 250mg Nicotinamide in a vegan HPMC capsule shell only. Zero fillers, zero binders, zero excipients.

Can I take this with blood thinners?

Consult your GP first — resveratrol may interact with anticoagulants (warfarin) and antiplatelet medications via CYP450 enzyme inhibition. Food supplement — not a medicine.

Is this suitable for vegans?

Yes — HPMC plant-derived capsule shell, not gelatin. Zero fillers.

What sizes are available?

30 · 60 · 120 · 180 capsules.

Where is this made?

In-house at our own facility in Southend-on-Sea, Essex, UK. 5 Star Food Hygiene Rating. 161,000+ verified sales. Trading since 2016.

Is this suitable during pregnancy?

Not recommended during pregnancy or breastfeeding. Consult your GP. Food supplement — not a medicine.

How does this differ from NMN + Resveratrol capsules?

This product contains B3 Nicotinamide (NAD+ precursor via salvage pathway) + Trans-Resveratrol. The NMN + Resveratrol capsules contain NMN (the direct NAD+ precursor, one step closer to NAD+) + Trans-Resveratrol. NMN and Nicotinamide enter the NAD+ pathway at different stages. Educational context only.

Walle T et al. (2004) — Resveratrol oral bioavailability less than 1% · Drug Metabolism and Disposition

Verdin E. (2015) — NAD+ in ageing, metabolism and neurodegeneration · Science

Christen et al. (2025) — NMN vs NR vs Niacin head-to-head · Nature Metabolism